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📤 Submitted via the FAIR3R shared account on behalf of: Laurent Bouri

🔗 FAIR3R dataset: 10.83249/uy9f4rpu

🧑‍🔬 Creators: bouri, laurent

• Species: Mus musculus
• Sex: Female
• Strain: C57BL/6NJ
• Gene: Apoe
• Allele: Apoe^{tm1(APOE*)Ljohn}
• Mutation Type: transgenic
• Mutation Description: Human APOE exons 2-4 were inserted into the mouse Apoe genomic sequence replacing mouse exons 2-4. In addition, human exon 4 and a stop codon are flanked by loxP sites followed by exon 4 from the APOE2 isoform, providing a conditional "switch".
• Gene Chromosome Location: FNWR01000136.1:554347-556363
• Molecules & Treatments: tamoxifen
• Diet: high fat diet
• Disease Model: Alzheimer disease 3
• Disease Source: Donor
• Phenotype: abnormal
• Tissue / Organ: brain
• Source Tissue: Skin-associated lymphoid tissue
• Source Cell Type: alveolar adventitial fibroblast

🏷️ Keywords:

• test

📅 Publication year: 2026